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doi: 10.3389/fimmu.2020.01965 Summary Keywords systemic lupus erythematosus, chimeric antigen receptor T-cell, CD19, BCMA, therapeutic strategy, clinical implications Citation Zhou J, Lei B, Shi F, Luo X, Wu K, Xu Y, Zhang Y, Liu R, Wang H, Zhou J and He X (2024) CAR T-cell therapy for systemic lupus erythematosus: current status and future perspectives

Its mechanism involves simultaneous modulation of multiple neurotrophic pathways: BDNF-like Activity: Components mimic brain-derived neurotrophic factor signaling, promoting neuronal survival and plasticity GDNF-like Activity: Glial cell line-derived neurotrophic factor-like effects support dopaminergic neuron survival CNTF-like Activity: Ciliary neurotrophic factor-like components support oligodendrocyte and motor neuron function Anti-apoptotic Effects: Reduces caspase-mediated neuronal apoptosis in ischemic and neurodegenerative models Amyloid Modulation: Some evidence suggests effects on amyloid precursor protein processing relevant to Alzheimer's disease research Fundamental Contrast: Dihexa represents a reductionist approach one molecule, one target (HGF/c-Met), exceptional potency

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