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In further embodiments, the invention encompasses a method of treating an NNMT-expressing cancer by administering a therapeutically effective amount of one or more cations of the invention and one or more cations chosen from Tables 3a and 3b

This is an emergency situation that may require surgical release (incision) of the affected compartment(s) to relieve the elevated pressure and restore blood flow and nerve function

The piriformis muscle and tendon travel over the top of the sciatic nerve as the nerve leaves the pelvis at the sciatic notch