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Preclinical studies were assessed for reproducibility of models, dosing regimens, and outcome measures, while clinical studies were examined for study design (randomized, controlled, blinded), sample size, and risk of bias

ARDS patients have been found to have dysregulated iron metabolism, as evidenced by elevated levels of total and non-heme iron in plasma and bronchoalveolar lavage fluid (BALF) when compared to healthy controls

Orotate (orotic acid): An essential and versatile molecule

We also added glutathione reductase Gor (1 M) and its co-substrate NADPH+H + (250 M), to ensure the retention of the reduced state of the exogenous glutathione (see Figure 6D for a schematic overview)