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Schpf B, Weissensteiner H, Schfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Giese I, et al

Excess amounts excrete through urine without causing harm

Western blot analysis confirmed robust DHODH downregulation in shDHODH-transduced A431 cells (Fig

Furthermore, this finding contradicted a previous study suggesting that inhibiting ACSL3 facilitated ferroptosis by reducing the availability of MUFAs, which are potent suppressors of ferroptosis 94