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At the molecular level, WECP mediates -Catenin accumulation by promoting Akt and GSK3 phosphorylation (Figure 4)

doi:10.1016/j.jaip.2023.03.007 12Waldron JL, Rose M, Vogrin S, et al

Am J Dis Child

Studies (42, 43) have shown that apigenin has a pro-apoptotic effect in human RA-FLS, and it can induce RA-FLS apoptosis by mediating ROS and oxidative stress activator ERK1/2, and mediate apoptotic cell death by activating the apoptotic effector caspase-3/7