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They concluded that the risk-edited cells increased a T cell activation profile following non-specific TCR engagement, which mimicked the observations exhibited by PTPN22 knockout cells, suggesting the risk variant acts as a loss-of-function mutant that reduces the ability of LYP to inhibit TCR activation (74)

Start with one peptide at a time, adding each new compound after at least one to two weeks of stable response to the previous one

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