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Interleukin-1 beta (IL-1) levels in plasma Plasma level of human interleukin-1 beta (IL-1) was measured according to the manufacturers protocols (Abcam Inc, Cambridge, MA, USA, catalog # Ab 46052)

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Crucially, the number of PET-active lesions strongly predicted future neurodegeneration, as more active lesions at baseline correlated with greater cortical atrophy and worsening disability over 2 years

Microbe-associated molecular patterns (MAMPs) are molecules found on bacterial surfaces (203) which interact with the immune cell receptors of the host to promote inflammation (204)