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Geologists posit that the first recorded course of the river, as noted by Spanish explorers and map makers, deviates from geologic rationality

Pfmdr1 86Y and haplotypes at Pfcrt 72-76 have been linked to chloroquine (CQ) as well as amodiaquine (AQ) resistance

Cuprizone induces mitochondrial injury and oxidative stress by increasing mitochondrial production of superoxide anions 4 , reducing copper-dependent cytochrome c oxidase and monoamine oxidase activity 1 , decreasing copper-zinc superoxide dismutase 5 and glutathione 6 antioxidant activity, and inhibiting electron transport chain complex IV 7

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