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doi: 10.3389/fphar.2016.00050 17 AtawodiS

Cellular hypertrophy is accompanied by increased expression of intermediate filament constituent proteins, including vimentin, nestin and mainly GFAP, which is the main component of intermediate filaments in adult astrocytes (Pekny and Pekna, 2004)

The interaction of the p53-DBD with the Bax RE results in DNA deformation, and its partial disordering around the spacer regions allows p53-DBD to unwind and compress this region to promote proteinprotein interactions