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Additionally, the differential binding affinity between D1467G and wt was calculated for all peaks detected in wt and D1467G by performing another Fishers exact test comparing the read coverages in IP between both conditions, similar to the enrichment analysis between IP and SMI, but without considering an additional log2 fold change threshold

Glutathione plays a critical role in supporting white blood cell function, helping the horse resist infections and recover faster from illness

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However, PARL inhibition by PARL-IN-1 reveals alternative PINK1 trafficking pathways, leading to the accumulation of MPP-cleaved PINK1 in the mitochondria and partial degradation of PINK1 by the IMM metalloprotease OMA1