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Schafer et al., 2012)

Particularly noteworthy, Cassia seed aqueous extract inhibits FASN expression via the AMPK/TFEB-mediated autophagy pathway ( /CPT-1A pathway ( 6 Limitations of preclinical evidence and appraisal of translational gaps While current clinical management of NAFLD primarily relies on lifestyle modifications and metabolic regulation interventionsincluding insulin sensitizers, antioxidants, and lipid-lowering agentsthese approaches can delay disease progression but rarely reverse hepatic steatosis and fibrosis