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Published research shows SIRT1 deacetylates the p65 subunit of NF-kB, reducing its ability to drive inflammatory gene expression

While periodontitis supports the protection against local microbial attack, this inflammatory reaction can also damage the surrounding cells and connective tissue structures, including alveolar bone causing tooth loss (5, 6)

Indeed, the levels of several tight junction proteins, measured by Western blots, including occludin and ZO-1 were decreased in hypertensive models in some studies [92, 94], but not others, where differences in colonic occludin or ZO-1 between hypertensive and normotensive animals was not detected when these were assessed by immunofluorescence [93]

It helps firm and smooth the skin while promoting hydration and elasticity