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This herbicide most intensively induced ROS synthesis in bacterial cells at 10 mg/L (up to over 170%) and 0.1 mg/L (up to over 150%)

Loss of NAD + levels results in impairment of mitochondria function, which leads to failure of essential metabolic processes (Klimova and Kristian, 2019

In cold tumors, expression of key chemokines such as CXCL9 and CXCL10 is often suppressed by epigenetic modifications

Given that low lactate dehydrogenase levels represent a high mitochondrial metabolic state, this finding is consistent with the observation that cells with high levels of lipoylated TCA enzymes and a hyperactive mitochondrial respiratory rate are more sensitive to elesclomol