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The targets of PCBP1 and PCBP2 include iron-dependent Egl-9 family hypoxia-inducible factor (EGLN/PHD) and hypoxia-inducible factor 1 subunit alpha inhibitor (HIF1AN/FIH1) that play a role in regulating the transcriptional activity of hypoxia-inducible factor 1 subunit alpha (HIF1A/HIF1) ( 2+ or purified Fe-PCBP1 restores the activity of EGLN ( 2+ and delivers it to ferritin