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On the other hand, the binding of acids occurs through their carboxylate group with one copper ion of the binuclear site

[PubMed: 7883854] 360

Neuroscience 335 , 207220 (2016)

It undergoes complex post-translational modifications, including deglycosylation by N-Glycanase 1 (NGLY1) in the cytoplasm and proteolytic cleavage by DNA Damage Inducible 1 Homolog 2 (DDI2), ultimately leading to the generation of an active transcription factor [176]