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[ref] A recent study of histamine intolerance patients found that they had a significantly higher abundance of histamine-secreting bacteria[ref] Histamine plus other biogenic amines: The DAO enzyme is also used by the body to break down other biogenic amines, including tyramine, putrescine, cadaverine, spermidine, and spermine

Reviews of the rodent work note that the mechanism doesnt involve the hormonal suppression or receptor desensitization that would predict tolerance or rebound, and that adipose SAM levels tend to normalize rather than crash under inhibition

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Neural tube defects Neural tube defects (NTD) may result in anencephaly or spina bifida, which are often fatal congenital malformations of the central nervous system