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When intestinal microecology is disrupted, LPS enters blood circulation, activates the Toll-like receptor 4 (TLR4) signaling, and upregulates the expression of the NF-B pathway, which in turn promotes the differentiation and activity of osteoclasts, leading to severe bone loss and osteoporosis (62)

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The co-administration of ferroptosis inducers and diacylglycerol acyltransferase inhibitors suppresses tumor growth in LC models resistant to multiple chemotherapeutic agents (93)