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SMAD deletion caused HGF upregulation, contributing to angiogenesis in mice [98]

You might notice: Uneven menstrual periods or no periods at all Headaches Nervousness Dizziness Acne Changes in appetite Weight gain Unwanted facial and body hair Hair loss Loss of bone mineral density Belly pain Bloating Breakthrough bleeding Fatigue Less interest in sex Weakness Allergic reaction (this is rare) Changes to your menstrual cycle are the most common side effects

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Generating sufficient safety evidence would require large-scale clinical trials involving thousands of participants