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Cauwels A, Janssen B, Buys E, et al

Dysbiosis-induced oxidative stress disrupts the intricate equilibrium of gut homeostasis, leading to an increased degree of immunological dysregulation (Pellon et al., 2021)

287 Consistent with this, upon VDR siRNA knockdown, the downregulation of TJ proteins, including CLDN1, ZO-1/2, and E-cadherin, and the reduction of TER were revealed, which were relieved by 1,25-dihydroxyvitamin D3 [1,25(OH) 2 D 3 ], suggesting the role of VDR-mediated vitamin D signaling in the regulation of TJs