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Scientific Context In laboratory settings, HLK-ML2 is examined for its activity in studies related to the melanocortin receptor family and associated cellular signaling mechanisms

Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and triptan receptors: implications in migraine

Brain tissue homogenates and serum samples were collected to quantify intestinal permeability markers (zonulin and occluding), oxidative-stress markers (GSH, MDA, CAT), and GABA-receptor gene expression using ELISA and biochemical assays