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These effects were mediated through the modulation of key molecular markers, including Bax, caspase-3, Beclin 1, LC3 I/II, mitochondrial membrane potential, Bcl-2, p-p65, p-IKK/, and p-IB [114]

Scientific study has also addressed its stability properties across biological matrices, pharmacokinetic behavior in preclinical species, and interaction with the dopaminergic system in controlled neurological research models

In the field of genetics, genome-wide association studies (GWAS) have highlighted a strong link between the LPA gene and PAD, indicating that therapeutic modulation of circulating Lp(a) could be effective for the PAD phenotype [137]