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Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity

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However, an overabundance of these oxidants can lead to tissue damage thereby contributing to chronic inflammatory diseases such as asthma, chronic obstructive pulmonary disease and atherosclerosis

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Mutations in either nuclear or mitochondrial genomes causing mitochondrial dysfunction lead to a diverse group of disorders known as primary mitochondrial diseases (MDs), affecting predominantly high energy-requiring organs/tissues 2,3

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