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Transcriptome analysis of microglia isolated from SOD1 G93A mice revealed increases in activated pro-inflammatory Igf1 , Progranulin, Trem2 , cytokines, and neurotoxic factor MMP-12 (Chiu et al., 2013)

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death