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Inhibition of PKC/ by auranofin increases SORLA levels, attenuates the SORLA-ARR2 interaction, and reduces amyloidogenic processing of APP in AD model mice Encouraged by our mechanistic studies demonstrating the critical role of the PKC/-ARR2 axis in disrupting the SORLA-retromer interaction and promoting SORLA lysosomal trafficking and degradation (illustrated in Fig

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Therefore, its worth asking your doctor to also check your active vitamin B12 levels (also known as holotranscobalamin II) and blood or urine levels of methylmalonic acid (5)

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