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Think of microneedling as an ongoing maintenance treatment rather than a one-time fix

doi:10.1038/labinvest.2013.52

Depending on the concentration and kinetics of calcium in the neurons, it can initiate two distinct signaling pathways via low-calcium-affinity kinase, CaMKII, or high-calcium-affinity phosphatase, calcineurin (Malenka and Bear, 2004

Blood 128:959970 Overdijk MB, Verploegen S, Bgels M, van Egmond M, Lammerts van Bueren JJ, Mutis T et al (2015) Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma