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doi: 10.1016/j.cmet.2019.03.011 70 SniderSAMargisonKDGhorbaniPLeBlondNDNunesJRCet al

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In contrast, Type-II iNOS (inducible NOS) is Ca2+ independent because its high affinity for Ca2+/Calm (Calmodulin) renders the enzyme active even at basal levels of intracellular Ca2+