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Single-cell communication maps reveal that microglia both initiate NSC necroptosis and respond to TSC2-rich exosomes via epidermal growth factor pathways, hinting at a negative-feedback circuit that tempers chronic inflammation ( Quercetin deflects microglial polarization and safeguards oligodendrocytes from necroptosis

The arginate salt form is a newer formulation designed for greater stability, particularly in liquid form and in the harsh environment of the GI tract

Clinical findings in depression and other psychiatric conditions suggest a possible synergistic effect with antidepressants [160,161], but randomized trials are scarce and overall inconclusive