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Kim ES, Lee JJ, He G, Chow CW, Fujimoto J, Kalhor N, Swisher SG , Wistuba II, Stewart DJ, Siddik ZH

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5.1.2 Thioredoxin reductase Thioredoxin reductase (TrxR) is a homodimeric enzyme that boasts a sophisticated architecture, featuring a flavin adenine dinucleotide (FAD) and a reduced nicotinamide adenine dinucleotide phosphate (NADPH) binding site for each of its monomers, thereby facilitating its essential role in cellular redox homeostasis (183)