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In the largest and longest follow-up study to date (up to 12 months), patients with mild AD underwent FUS targeting the hippocampus, frontal, and parietal lobes, with no serious adverse events, full BBB closure within 48 h, and cognitive outcomes comparable to those seen with natural disease progression (Rezai et al., 2022)

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Through interdisciplinary integration and a combined approach of traditional Chinese and Western medicine, this field may overcome current diagnostic and therapeutic bottlenecks, ultimately shifting the paradigm from delaying disease progression to reversing renal injury