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Idebenone has been shown to inhibit the Src homology and collagen (Shc) adaptor proteins, thereby reducing mitochondrial oxidative stress, inflammation, and subsequent hepatic fibrosis in preclinical studies

Most individuals adapt quickly, though some may initially experience mild hunger or fatigue

In contrast, safinamide, a reversible inhibitor of MAO-B enzyme and Glu release and LJP-1207, a selective SSAO inhibitor with antioxidant and anti-inflammatory effects, and as such, compounds with considerable pharmacodynamic overlap with selegiline, but different, non-propargylamine structures, failed to be otoprotective in AGIHL

[DOI] [Google Scholar] 11.Palamakula A., Soliman M., Khan M.M