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It is catalysed by glutamate-cysteine ligase, historically called gamma-glutamylcysteine synthetase

on the other hand, whole-body fat accumulation leads to metabolic and hormonal imbalance that increases systemic inflammation, a key factor in COPD [33,34]

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6 Clinical relevance and translational potential of mtDNA monitoring The growing understanding of mtDNAs role in HIV pathogenesis and ART-related toxicity has stimulated interest in its value as a clinically actionable biomarker