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Here are some of the signs of B12 deficiency to look out for: Numbness, tingling, or a pins and needles feeling in the hands or feet (even if slight or minor) Falling or losing your footing more than usual or without reason Not being able to stay balanced Stiff muscles Vision changes Symptoms of psychosis (e.g., hallucinations, paranoia, disorganized thoughts, or schizophrenia-like symptoms) Severe or unusual tiredness Memory issues Sometimes, these symptoms can develop gradually

The primary outcome measure was the ACR20 response at 24 weeks, with ACR50/70/90, DAS28, EULAR response criteria, and time to ACR20 as secondary outcome measures

Monitoring is another critical component

2008 Sep Omar Ahmed Abdelwahab, Ahmed Abdelaziz, Sherein Diab, Ali khazragy, Toka Elboraay, Taha Fayad, Rehab Adel Diab, Ahmed Negida