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Arginine deiminase (ADI) ADI is an enzyme that catalyzes the interconversion of arginine and citrulline

However, most of prior studies frequently grouped diverse P-gp inhibitors together, but when examined at the individual drug level, sample sizes were insufficient limiting statistical power [13, 26,27,28]

27,28,29 But it was not until the discovery of signaling mediators small (Sma) in Caenorhabditis elegans and mothers against decapentaplegic (Mad) in Drosophila melanogaster that the homologous small mothers against decapentaplegic (SMAD) proteins were identified as the canonical signal transducers of TGF- signaling in humans in 1996

PMID 16348793