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Alcohol also reduces glutathione production, which means NAPQI is more likely to accumulate in the liver at dangerous concentrations

Lazard D, Zupko K, Poria Y, Nef P, Lazarovits J, Horn S et al

Okuyama, Pharmacol

[ Links ] Egashira N, Matsuda T, Koushi E, Higashihara F, Mishima K, Chidori S, Hasebe N, Iwasaki K, Nishimura R, Oishi R, Fujiwara M (2008) 9-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: Involvement of cannabinoid CB1 receptor and serotonergic system