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Moreover, when SRS imaging was used to detect the localization of a diyne ferrostatin, no detectable signal was found in the plasma membrane

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Under normoxic conditions, HIF-1 is rapidly hydroxylated by prolyl hydroxylase domain (PHD) enzymes, which promotes its recognition by the von HippelLindau (VHL) E3 ubiquitin ligase complex, leading to ubiquitination and subsequent proteasomal degradation (Zhang et al., 2025)