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In adults, GHRH maintains and manages growth, usually in the bones, muscles and tissues

Secreting and sensing the same molecule allows cells to achieve versatile social behaviors

Dynamic remodeling of ECM is a hallmark of skin aging With aging, epidermal thickness decreases rete ridges flatten, and the skins moisturizing and barrier functions are compromised under the influence of gene-regulated cellular senescence 8 , extracellular matrix degradation due to oxidative stress 9 , and remodeling of the extracellular matrix by advanced glycation end products (AGEs) 10,11,12

DOI: 10.1210/mend.10.8.8843412 Chen, J.D., Umesono, K., Evans, R.M