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These virus-induced vesicles could damage mitochondrial membrane integrity, release mt-DNA into circulation, compromise innate immunity, and trigger an exacerbated pro-inflammatory response in COVID-19 patients 164

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Therefore, as expected we found increased mRNA expression of Gsr and other NRF2-regulated genes ( Gclm , Nqo1 , Srxn1 and Hmox1 ) (Fig 2A), as well as NRF2 and GSR protein abundance (Fig 2B) in LPS-stimulated RAW264.7 Ms with accumulated oxLDL