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Complementary modulation of somatic inhibition by opioids and cannabinoids

What Is BPC-157 and How Does It Support Healing

PLoS One 7, e43019 (2012)

The JNKs, specifically the JNK1 isoform, would be a direct inhibitor of the insulin receptor substrate 1, the substrate of the insulin receptor, being its activation cause for a reduction of insulin signaling and glucose up-take, an already described symptom of possible appearance of AD [5, 13, 96]