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Abrupt discontinuation of Li can lead to a higher risk of recurrence compared to before starting treatment, which is considered an iatrogenic harm known as the rebound phenomenon 6

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While the tyrosine kinase activity of IGF-1R is needed for downstream AKT activation, MAPK activation takes place without it (60), requiring in this case the C-terminal region of the receptor (61)

J Pharmacogn Phytochem 7:23842386 Lagriffoul A, Mocquot B, Mench M, Vangronsveld J (1998) Cadmium toxicity effects on growth, mineral and chlorophyll contents, and activities of stress related enzymes in young maize plants ( Zea mays L.)