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Hepatitis C in Egyptpast, present, and future

BMC Plant Biol 16:87112

Challenges, considerations and principles to guide trials of combination therapies for chronic HBV infection

The major translational challenges include achieving sufficient tumor-specific accumulation over healthy tissues (especially for intravenous delivery), overcoming the heterogeneity and adaptability of the TME that may diminish catalytic efficacy, and addressing potential long-term toxicity of Pt accumulation