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Although overexpression of oncogenes such as cyclin E1 or CDC25A has been shown to induce fork reversal 26 , the role of R-loops in these processes has not yet been investigated

The heart-brain axis (HBA) disorders The HBA constitutes a bidirectionally interconnected neurohumoral interface, mediated by autonomic neural circuits, endocrine-cytokine cross-talk, and hemodynamic signaling networks, which collectively underpin the pathophysiology of shared cardio-cerebral disorders

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