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Based on these findings, we propose that the multiple cell death pathways induced by Erastin in EMS create a tightly regulated positive feedback network centered around free iron and ROS

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In addition, three monoclonal antibodies (mAbs) were immobilized to generate a trispecific nanobody Tri-Nab by using optimized albumin/polyester composite nanoparticles conjugated with anti-Fc antibodies, which can simultaneously target PDL1, 4-1BB, and NKG2A (or TIGIT), and can effectively bind NK cells and CD8 + T cells, inducing their activation and proliferation thereby achieving efficient tumor killing (177)