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As a measure of mitophagy, mitolysosomes were quantified in sectioned retina immunolabeled with RBPMS for RGCs or vimentin for Mller glia

MBio 11:19

Glucose-6-phosphate will metabolically trifurcate into the following pathways: (i) conversion to fructose-6-phosphate by the enzyme phosphoglucose isomerase, entering the glycolytic pathway, or (ii) oxidation by glucose-6-phosphate dehydrogenase to 6-phosphogluconolactone, thereby initiating the oxidative phase of the pentose phosphate pathway

In sALS patients, deregulation of the cellular redox systems has been suggested by higher free radical levels found in the blood and serum of patients[32, 73], and evidence of oxidative damage includes the increase in protein carbonyls[34, 35, 74, 75], 8-OHdG[47, 49], MDA-modified proteins[34], 4-HNE protein conjugates[36, 76], and nitrotyrosine products[7779] in the spinal cord