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Intestinal transcriptome analysis revealed differential salinity adaptation between two tilapiine species

Pharmacol Res 146:104321 Bjrklund G, Shanaida M, Lysiuk R, Antonyak H, Klishch I, Shanaida V, Peana M (2022) Selenium: an antioxidant with a critical role in anti-aging

It's also involved in 5 : Neutralizing singlet oxygen, hydroxyl radicals, and superoxide radials Serving a cofactor for antioxidant enzymes Regenerating vitamin C and E Neutralizing free radicals produced during Phase 1 liver metabolism of toxins Transporting mercury out of cells and the brain Regulating cell proliferation and apoptosis Supporting mitochondrial function Maintaining mitochondrial DNA Aside from its antioxidant role, one of the other key functions it's involved in is detoxifying both xenobiotic and endogenous compounds 5

Despite its lower reactivity, HO becomes highly damaging in the presence of transition metals such as iron or copper, where it can generate the highly reactive hydroxyl radical (OH) [28]