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For those who exercise regularly, dietary glutamine is essentially an anabolic amino acid contributing to growth hormone release and replenishing cannibalized stores of lean muscle amino acids recruited to support exercise expense

doi: 10.1016/j.lfs.2013.12.029

Under the induction of oxidative stress, a part of HIF-1 is translocated to mitochondria, where it inhibits the respiratory chain by lowering the expression of mtDNA-encoded mRNA that responses to hypoxia, thus preventing the over-production of ROS and resisting oxidative stress