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In 1992, Wright and Harding identified binding sites for the hexapeptide Ang IV in several brain areas associated with cognition, motor and sensory physiological functions (Swanson et al., 1992), e.g., in hippocampus (Harding et al., 1992)

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Although data in humans is lacking, the bioavailability may be somewhat greater than the sublingual route (perhaps roughly on the order of 50%)

There is also limited knowledge of the implications of these mutations with regard to development of severe hemolytic disease in the United States population. Hmm