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Across multiple tissues, FGF21 appears to counteract ER stress (101, 112, 113)

What the evidence suggests: dermatological observations have noted skin-brightening effects, particularly in hyperpigmentation, melasma, and post-inflammatory darkening

Moreover, the same NO/cGMP signaling was effective in survival cell response to GSH depletion in skeletal muscle cells ( On the basis of these knowledge, it is not surprising that alterations in GSH homeostasis have been implicated in the etiology and/or progression of many human diseases ( In this review we briefly summarize the mechanisms of GSH synthesis and homeostasis, while we will focus on the strict connection between GSH levels and oxidative/nitrosative stress and on the downstream redox changes that modulate signaling pathways involved in viral infection and autophagy (ATG)

Lin et al., 2020)