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While BPA binding to extranuclear ER can trigger MAPK pathway activation 78 , the observed activation of the intracellular kinase pathways observed here more probably occurred via BPA binding to GPER, the G-protein coupled ER, as membrane bound ERs have not been identified in zebrafish 74

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This mechanistically supports the use of such vitamin antioxidant combinations for DR [44, 50]

those that have suggest similar rates [21]