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You may experience heightened nervousness, difficulty concentrating, or persistent worrying despite a lack of reason for concern

Proper site rotation, using room-temperature medication, inserting the needle at 90 degrees, and allowing adequate time between injections in the same area all reduce unnecessary discomfort

Although CHKs did not show differential expression at 24 hours post-treatment, it is plausible that such changes may manifest at later timepoints subsequent to RRM2 downregulation

Management includes ensuring adequate nutrition, potentially slowing weight loss rate, and specialist referral if amenorrhoea persists beyond six months