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Description

Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s

Chakraborty C, Mitra S, Roychowdhury A, Samadder S, Dutta S, Roy A

Functional studies in zebrafish have provided in vivo evidence that disruption of Pgrmc1 (progesterone receptor membrane component 1)a membrane-associated protein that physically interacts with CYP51A1leads to cataract formation, likely due to impaired CYP51A1 activity and dysregulated cholesterol metabolism [48]